RT Journal Article
SR Electronic
T1 Early origins of lung disease: towards an interdisciplinary approach
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 200191
DO 10.1183/16000617.0191-2020
VO 29
IS 157
A1 Niki D.J. Ubags
A1 Miguel A. Alejandre Alcazar
A1 Suhas G. Kallapur
A1 Sylvia Knapp
A1 Sophie Lanone
A1 Clare M. Lloyd
A1 Rory E. Morty
A1 Céline Pattaroni
A1 Niki L. Reynaert
A1 Robbert J. Rottier
A1 Hermelijn H. Smits
A1 Wouter A.A. de Steenhuijsen Piters
A1 Deborah H. Strickland
A1 Jennifer J.P. Collins
YR 2020
UL http://err.ersjournals.com/content/29/157/200191.abstract
AB The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and immune maturation on the development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time point are detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the European Respiratory Society Research Seminar “Early origins of lung disease: towards an interdisciplinary approach” (Lisbon, Portugal, November 2019).Future research into early origins of lung disease should be centred around four major focus areas: 1) policy and education, 2) clinical assessment, 3) basic and translational research and 4) infrastructure and tools https://bit.ly/2FHqWmP