RT Journal Article
SR Electronic
T1 Airway mechanical compression: its role in asthma pathogenesis and progression
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 190123
DO 10.1183/16000617.0123-2019
VO 29
IS 157
A1 Veerati, Punnam Chander
A1 Mitchel, Jennifer A.
A1 Reid, Andrew T.
A1 Knight, Darryl A.
A1 Bartlett, Nathan W.
A1 Park, Jin-Ah
A1 Grainge, Chris L.
YR 2020
UL http://err.ersjournals.com/content/29/157/190123.abstract
AB The lung is a mechanically active organ, but uncontrolled or excessive mechanical forces disrupt normal lung function and can contribute to the development of disease. In asthma, bronchoconstriction leads to airway narrowing and airway wall buckling. A growing body of evidence suggests that pathological mechanical forces induced by airway buckling alone can perpetuate disease processes in asthma. Here, we review the data obtained from a variety of experimental models, including in vitro, ex vivo and in vivo approaches, which have been used to study the impact of mechanical forces in asthma pathogenesis. We review the evidence showing that mechanical compression alters the biological and biophysical properties of the airway epithelium, including activation of the epidermal growth factor receptor pathway, overproduction of asthma-associated mediators, goblet cell hyperplasia, and a phase transition of epithelium from a static jammed phase to a mobile unjammed phase. We also define questions regarding the impact of mechanical forces on the pathology of asthma, with a focus on known triggers of asthma exacerbations such as viral infection.Bronchoconstriction in asthma is not only a symptom but is also a disease modifier. Targeting downstream mediators of mechanical force induction may provide opportunities for novel therapies for asthma and its exacerbations. http://bit.ly/2UktQDj