RT Journal Article
SR Electronic
T1 Minimal clinically important difference for asthma endpoints: an expert consensus report
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 190137
DO 10.1183/16000617.0137-2019
VO 29
IS 156
A1 Matteo Bonini
A1 Marcello Di Paolo
A1 Diego Bagnasco
A1 Ilaria Baiardini
A1 Fulvio Braido
A1 Marco Caminati
A1 Elisiana Carpagnano
A1 Marco Contoli
A1 Angelo Corsico
A1 Stefano Del Giacco
A1 Enrico Heffler
A1 Carlo Lombardi
A1 Ilaria Menichini
A1 Manlio Milanese
A1 Nicola Scichilone
A1 Gianenrico Senna
A1 Giorgio W. Canonica
YR 2020
UL http://err.ersjournals.com/content/29/156/190137.abstract
AB Minimal clinically important difference (MCID) can be defined as the smallest change or difference in an outcome measure that is perceived as beneficial and would lead to a change in the patient's medical management.The aim of the current expert consensus report is to provide a “state-of-the-art” review of the currently available literature evidence about MCID for end-points to monitor asthma control, in order to facilitate optimal disease management and identify unmet needs in the field to guide future research.A series of MCID cut-offs are currently available in literature and validated among populations of asthmatic patients, with most of the evidence focusing on outcomes as patient reported outcomes, lung function and exercise tolerance. On the contrary, only scant and partial data are available for inflammatory biomarkers. These clearly represent the most interesting target for future development in diagnosis and clinical management of asthma, particularly in view of the several biologic drugs in the pipeline, for which regulatory agencies will soon require personalised proof of efficacy and treatment response predictors.Minimal clinically important difference (MCID) cut-offs in asthma are validated for patient reported outcomes and lung function, but not for inflammatory biomarkers. MCID represents a key target for future development in asthma management. http://bit.ly/33hcWIe