TY - JOUR T1 - The biology of pulmonary exacerbations in bronchiectasis JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0055-2019 VL - 28 IS - 154 SP - 190055 AU - Francesco Amati AU - Edoardo Simonetta AU - Andrea Gramegna AU - Paolo Tarsia AU - Martina Contarini AU - Francesco Blasi AU - Stefano Aliberti Y1 - 2019/12/31 UR - http://err.ersjournals.com/content/28/154/190055.abstract N2 - Bronchiectasis is a heterogeneous chronic disease. Heterogeneity characterises bronchiectasis not only in the stable state but also during exacerbations, despite evidence on clinical and biological aspects of bronchiectasis, exacerbations still remain poorly understood.Although the scientific community recognises that bacterial infection is a cornerstone in the development of bronchiectasis, there is a lack of data regarding other trigger factors for exacerbations. In addition, a huge amount of data suggest a primary role of neutrophils in the stable state and exacerbation of bronchiectasis, but the inflammatory reaction involves many other additional pathways. Cole's vicious cycle hypothesis illustrates how airway dysfunction, airway inflammation, infection and structural damage are linked. The introduction of the concept of a “vicious vortex” stresses the complexity of the relationships between the components of the cycle. In this model of disease, exacerbations work as a catalyst, accelerating the progression of disease. The roles of microbiology and inflammation need to be considered as closely linked and will need to be investigated in different ways to collect samples. Clinical and translational research is of paramount importance to achieve a better comprehension of the pathophysiology of bronchiectasis, microbiology and inflammation both in the stable state and during exacerbations.“The hardest thing of all is to find a black cat in a dark room, especially if there is no cat.” There is a lack of knowledge about exacerbation of bronchiectasis. Future efforts are required to better define the biology of exacerbations. http://bit.ly/2XgjaHG ER -