TY - JOUR T1 - Integration of drug safety monitoring in tuberculosis treatment programmes: country experiences JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0115-2018 VL - 28 IS - 153 SP - 180115 AU - Edine Tiemersma AU - Susan van den Hof AU - Gunta Dravniece AU - Fraser Wares AU - Yohannes Molla AU - Yusie Permata AU - Endang Lukitosari AU - Mamel Quelapio AU - Si Thu Aung AU - Khay Mar Aung AU - Hoang Thanh Thuy AU - Vu Dinh Hoa AU - Merkinai Sulaimanova AU - Saadat Sagyndikova AU - Mavluda Makhmudova AU - Alijon Soliev AU - Michael Kimerling Y1 - 2019/09/30 UR - http://err.ersjournals.com/content/28/153/180115.abstract N2 - Active drug safety monitoring and management (aDSM) is being recommended by the World Health Organization for new drugs and regimens for drug-resistant tuberculosis. Early experience with aDSM shows that collaboration and capacity building of pharmacovigilance and TB programmes are crucial http://bit.ly/2meWkiVNew drugs and shorter treatments for drug-resistant tuberculosis (DR-TB) have become available in recent years and active pharmacovigilance (PV) is recommended by the World Health Organization (WHO) at least during the early phases of implementation, with active drug safety monitoring and management (aDSM) proposed for this. We conducted a literature review of papers reporting on aDSM. Up to 18 April, 2019, results have only been published from one national aDSM programme. Because aDSM is being introduced in many low- and middle-income countries, we also report experiences in introducing it into DR-TB treatment programmes, targeting the reporting of a restricted set of adverse events (AEs) as per WHO-recommended aDSM principles for the period 2014–2017. Early beneficial effects of active PV for TB patients include increased awareness about the occurrence, detection and management of AEs during TB treatment, and the increase of spontaneous reporting in some countries. However, because PV capacity is low in most countries and collaboration between national TB programmes and national PV centres remains weak, parallel and coordinated co-development of the capacities of both TB programmes and PV centres is needed. ER -