RT Journal Article SR Electronic T1 The genetics of interstitial lung diseases JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 190053 DO 10.1183/16000617.0053-2019 VO 28 IS 153 A1 Borie, Raphael A1 Le Guen, Pierre A1 Ghanem, Mada A1 Taillé, Camille A1 Dupin, Clairelyne A1 Dieudé, Philippe A1 Kannengiesser, Caroline A1 Crestani, Bruno YR 2019 UL http://err.ersjournals.com/content/28/153/190053.abstract AB Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD.Common and rare genetic variants contribute to the development and clinical manifestation of many interstitial lung diseases http://bit.ly/31loHLh