RT Journal Article
SR Electronic
T1 The genetics of interstitial lung diseases
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 190053
DO 10.1183/16000617.0053-2019
VO 28
IS 153
A1 Raphael Borie
A1 Pierre Le Guen
A1 Mada Ghanem
A1 Camille Taillé
A1 Clairelyne Dupin
A1 Philippe Dieudé
A1 Caroline Kannengiesser
A1 Bruno Crestani
YR 2019
UL http://err.ersjournals.com/content/28/153/190053.abstract
AB Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD.Common and rare genetic variants contribute to the development and clinical manifestation of many interstitial lung diseases http://bit.ly/31loHLh