PT  - JOURNAL ARTICLE
AU  - Raphael Borie
AU  - Pierre Le Guen
AU  - Mada Ghanem
AU  - Camille Taillé
AU  - Clairelyne Dupin
AU  - Philippe Dieudé
AU  - Caroline Kannengiesser
AU  - Bruno Crestani
TI  - The genetics of interstitial lung diseases
AID  - 10.1183/16000617.0053-2019
DP  - 2019 Sep 30
TA  - European Respiratory Review
PG  - 190053
VI  - 28
IP  - 153
4099  - http://err.ersjournals.com/content/28/153/190053.short
4100  - http://err.ersjournals.com/content/28/153/190053.full
SO  - EUROPEAN RESPIRATORY REVIEW2019 Sep 30; 28
AB  - Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD.Common and rare genetic variants contribute to the development and clinical manifestation of many interstitial lung diseases http://bit.ly/31loHLh