TY - JOUR T1 - The genetics of interstitial lung diseases JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0053-2019 VL - 28 IS - 153 SP - 190053 AU - Raphael Borie AU - Pierre Le Guen AU - Mada Ghanem AU - Camille Taillé AU - Clairelyne Dupin AU - Philippe Dieudé AU - Caroline Kannengiesser AU - Bruno Crestani Y1 - 2019/09/30 UR - http://err.ersjournals.com/content/28/153/190053.abstract N2 - Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD.Common and rare genetic variants contribute to the development and clinical manifestation of many interstitial lung diseases http://bit.ly/31loHLh ER -