RT Journal Article SR Electronic T1 What have we learned from basic science studies on idiopathic pulmonary fibrosis? JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 190029 DO 10.1183/16000617.0029-2019 VO 28 IS 153 A1 Yanagihara, Toyoshi A1 Sato, Seidai A1 Upagupta, Chandak A1 Kolb, Martin YR 2019 UL https://publications.ersnet.org//content/28/153/190029.abstract AB Idiopathic pulmonary fibrosis is a fatal age-related lung disease characterised by progressive and irreversible scarring of the lung. Although the details are not fully understood, there has been tremendous progress in understanding the pathogenesis of idiopathic pulmonary fibrosis, which has led to the identification of many new potential therapeutic targets. In this review we discuss several of these advances with a focus on genetic susceptibility and cellular senescence primarily affecting epithelial cells, activation of profibrotic pathways, disease-enhancing fibrogenic cell types and the role of the remodelled extracellular matrix.This review provides a summary of the most important findings in basic science investigations in pulmonary fibrosis and how they affect drug development and future patient management. http://bit.ly/2RjGMFZ