PT  - JOURNAL ARTICLE
AU  - Invernizzi, Rachele
AU  - Molyneaux, Philip L.
TI  - The contribution of infection and the respiratory microbiome in acute exacerbations of idiopathic pulmonary fibrosis
AID  - 10.1183/16000617.0045-2019
DP  - 2019 Jun 30
TA  - European Respiratory Review
PG  - 190045
VI  - 28
IP  - 152
4099  - http://err.ersjournals.com/content/28/152/190045.short
4100  - http://err.ersjournals.com/content/28/152/190045.full
SO  - EUROPEAN RESPIRATORY REVIEW2019 Jun 30; 28
AB  - Idiopathic pulmonary fibrosis (IPF) arises in genetically susceptible individuals as a result of an aberrant wound-healing response following repetitive alveolar injury. The clinical course of the disease remains both variable and unpredictable with periods of more rapid decline, termed acute exacerbation of IPF (AE-IPF), often punctuating the disease trajectory. Exacerbations carry a significant morbidity and mortality, and their exact pathogenesis remains unclear. Given the emerging evidence that disruption and alteration in the lung microbiome plays a role in the pathogenesis and progression of IPF, this review discusses the current knowledge of the contribution of infection and the respiratory microbiome to AE-IPF.Microbial dysbosis plays a role in the pathogenesis of IPF and further changes occur during acute exacerbations despite exclusion of overt infection. http://bit.ly/2MQkfBN