TY - JOUR T1 - Breath analysis of cancer in the present and the future JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0002-2019 VL - 28 IS - 152 SP - 190002 AU - Reef Einoch Amor AU - Morad K. Nakhleh AU - Orna Barash AU - Hossam Haick Y1 - 2019/06/30 UR - http://err.ersjournals.com/content/28/152/190002.abstract N2 - Most of the currently used diagnostics for cancerous diseases have yet to meet the standards of screening, as they are insufficiently accurate and/or invasive and risky. In this review, we describe the rationale, the progress made to date, and the potential of analysing the exhaled volatile organic compounds as a pathway for enabling early diagnosis of cancer and, therefore, for achieving better clinical prognosis and survival rates. The review highlights the major advancements made in this field, from fundamentals, up to translational phases and clinical trials, with a special emphasis on sensing platforms based on nanomaterials. The prospects for breath analysis in early cancerous disease are presented and discussed.Breath volatolomics is a highly promising frontier in non-/minimally invasive personalised and evidence-based cancer medicine that could be implemented for a wide variety of cancers in a noninvasive, affordable and easy-to-use manner http://bit.ly/2XeMsDb ER -