PT  - JOURNAL ARTICLE
AU  - Reef Einoch Amor
AU  - Morad K. Nakhleh
AU  - Orna Barash
AU  - Hossam Haick
TI  - Breath analysis of cancer in the present and the future
AID  - 10.1183/16000617.0002-2019
DP  - 2019 Jun 30
TA  - European Respiratory Review
PG  - 190002
VI  - 28
IP  - 152
4099  - http://err.ersjournals.com/content/28/152/190002.short
4100  - http://err.ersjournals.com/content/28/152/190002.full
SO  - EUROPEAN RESPIRATORY REVIEW2019 Jun 30; 28
AB  - Most of the currently used diagnostics for cancerous diseases have yet to meet the standards of screening, as they are insufficiently accurate and/or invasive and risky. In this review, we describe the rationale, the progress made to date, and the potential of analysing the exhaled volatile organic compounds as a pathway for enabling early diagnosis of cancer and, therefore, for achieving better clinical prognosis and survival rates. The review highlights the major advancements made in this field, from fundamentals, up to translational phases and clinical trials, with a special emphasis on sensing platforms based on nanomaterials. The prospects for breath analysis in early cancerous disease are presented and discussed.Breath volatolomics is a highly promising frontier in non-/minimally invasive personalised and evidence-based cancer medicine that could be implemented for a wide variety of cancers in a noninvasive, affordable and easy-to-use manner http://bit.ly/2XeMsDb