PT  - JOURNAL ARTICLE
AU  - Dina Hashoul
AU  - Hossam Haick
TI  - Sensors for detecting pulmonary diseases from exhaled breath
AID  - 10.1183/16000617.0011-2019
DP  - 2019 Jun 30
TA  - European Respiratory Review
PG  - 190011
VI  - 28
IP  - 152
4099  - http://err.ersjournals.com/content/28/152/190011.short
4100  - http://err.ersjournals.com/content/28/152/190011.full
SO  - EUROPEAN RESPIRATORY REVIEW2019 Jun 30; 28
AB  - This review presents and discusses a new frontier for fast, risk-free and potentially inexpensive diagnostics of respiratory diseases by detecting volatile organic compounds (VOCs) present in exhaled breath. One part of the review is a didactic presentation of the overlaying concept and the chemistry of exhaled breath. The other part discusses diverse sensors that have been developed and used for the detection of respiratory diseases (e.g. chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, tuberculosis, cystic fibrosis, obstructive sleep apnoea syndrome and pneumoconiosis) by analysis of VOCs in exhaled breath. The strengths and pitfalls are discussed and criticised, particularly in the perspective in disseminating information regarding these advances. Ideas regarding the improvement of sensors, sensor arrays, sensing devices and the further planning of workflow are also discussed.Detection of volatile organic compounds from exhaled breath by nanomaterial-based sensors is a new diagnostics frontier in the screening of pulmonary diseases. http://bit.ly/2JoBKXn