RT Journal Article
SR Electronic
T1 Receptor for advanced glycation end-products and environmental exposure related obstructive airways disease: a systematic review
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 180096
DO 10.1183/16000617.0096-2018
VO 28
IS 151
A1 Haider, Syed H.
A1 Oskuei, Assad
A1 Crowley, George
A1 Kwon, Sophia
A1 Lam, Rachel
A1 Riggs, Jessica
A1 Mikhail, Mena
A1 Talusan, Angela
A1 Veerappan, Arul
A1 Kim, James S.
A1 Caraher, Erin J.
A1 Nolan, Anna
YR 2019
UL http://err.ersjournals.com/content/28/151/180096.abstract
AB Background Our group has identified the receptor for advanced glycation end-products (RAGE) as a predictor of World Trade Center particulate matter associated lung injury. The aim of this systematic review is to assess the relationship between RAGE and obstructive airways disease secondary to environmental exposure.Methods A comprehensive search using PubMed and Embase was performed on January 5, 2018 utilising keywords focusing on environmental exposure, obstructive airways disease and RAGE and was registered with PROSPERO (CRD42018093834). We included original human research studies in English, focusing on pulmonary end-points associated with RAGE and environmental exposure.Results A total of 213 studies were identified by the initial search. After removing the duplicates and applying inclusion and exclusion criteria, we screened the titles and abstracts of 61 studies. Finally, 19 full-text articles were included. The exposures discussed in these articles include particulate matter (n=2) and cigarette smoke (n=17).Conclusion RAGE is a mediator of inflammation associated end-organ dysfunction such as obstructive airways disease. Soluble RAGE, a decoy receptor, may have a protective effect in some pulmonary processes. Overall, RAGE is biologically relevant in environmental exposure associated lung disease. Future investigations should focus on further understanding the role and therapeutic potential of RAGE in particulate matter exposure associated lung disease.RAGE is biologically relevant in environmental exposure associated lung disease. Future investigations should focus on further understanding the role and therapeutic potential of RAGE in particulate matter exposure associated lung disease http://ow.ly/gfZz30o7otU