TY - JOUR T1 - Precision medicine and personalising therapy in pulmonary hypertension: seeing the light from the dawn of a new era JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0004-2018 VL - 27 IS - 148 SP - 180004 AU - Laurent Savale AU - Christophe Guignabert AU - Jason Weatherald AU - Marc Humbert Y1 - 2018/06/30 UR - http://err.ersjournals.com/content/27/148/180004.abstract N2 - Pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) include different cardiopulmonary disorders in which the interaction of multiple genes with environmental and behavioural factors modulates the onset and the progression of these severe conditions. Although the development of therapeutic agents that modulate abnormalities in three major pathobiological pathways for PAH has revolutionised our approach to the treatment of PAH, the long-term survival rate remains unsatisfactory. Accumulating evidence has underlined that clinical outcomes and responses to therapy in PAH are modified by multiple factors, including genetic variations, which will be different for each individual. Since precision medicine, also known as stratified medicine or personalised medicine, aims to better target intervention to the individual while maximising benefit and minimising harm, it has significant potential advantages. This article aims to assemble and discuss the different initiatives that are currently underway in the PH/PAH fields together with the opportunities and prospects for their use in the near future.Development of precision medicine strategies will be the next frontier in the evolution of PAH treatment http://ow.ly/8T8730j7e36 ER -