TY - JOUR T1 - Personalised medicine in sleep respiratory disorders: focus on obstructive sleep apnoea diagnosis and treatment JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0069-2017 VL - 26 IS - 146 SP - 170069 AU - Maria R. Bonsignore AU - Monique C. Suarez Giron AU - Oreste Marrone AU - Alessandra Castrogiovanni AU - Josep M. Montserrat Y1 - 2017/12/31 UR - http://err.ersjournals.com/content/26/146/170069.abstract N2 - In all fields of medicine, major efforts are currently dedicated to improve the clinical, physiological and therapeutic understanding of disease, and obstructive sleep apnoea (OSA) is no exception. The personalised medicine approach is relevant for OSA, given its complex pathophysiology and variable clinical presentation, the interactions with comorbid conditions and its possible contribution to poor outcomes. Treatment with continuous positive airway pressure (CPAP) is effective, but CPAP is poorly tolerated or not accepted in a considerable proportion of OSA patients. This review summarises the available studies on the physiological phenotypes of upper airway response to obstruction during sleep, and the clinical presentations of OSA (phenotypes and clusters) with a special focus on our changing attitudes towards approaches to treatment. Such major efforts are likely to change and expand treatment options for OSA beyond the most common current choices (i.e. CPAP, mandibular advancement devices, positional treatment, lifestyle changes or upper airway surgery). More importantly, treatment for OSA may become more effective, being tailored to each patient's need.Physiological and clinical phenotyping of OSA patients will improve the management of the disease http://ow.ly/qSxq30f9Hp8 ER -