RT Journal Article
SR Electronic
T1 Systems medicine advances in interstitial lung disease
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 170021
DO 10.1183/16000617.0021-2017
VO 26
IS 145
A1 Greiffo, Flavia R.
A1 Eickelberg, Oliver
A1 Fernandez, Isis E.
YR 2017
UL http://err.ersjournals.com/content/26/145/170021.abstract
AB Fibrotic lung diseases involve subject–environment interactions, together with dysregulated homeostatic processes, impaired DNA repair and distorted immune functions. Systems medicine-based approaches are used to analyse diseases in a holistic manner, by integrating systems biology platforms along with clinical parameters, for the purpose of understanding disease origin, progression, exacerbation and remission.Interstitial lung diseases (ILDs) refer to a heterogeneous group of complex fibrotic diseases. The increase of systems medicine-based approaches in the understanding of ILDs provides exceptional advantages by improving diagnostics, unravelling phenotypical differences, and stratifying patient populations by predictable outcomes and personalised treatments. This review discusses the state-of-the-art contributions of systems medicine-based approaches in ILDs over the past 5 years.Systems medicine provides critical advances in understanding and molecular fingerprinting interstitial lung diseases http://ow.ly/phXg30dWVvv