RT Journal Article
SR Electronic
T1 Endoplasmic reticulum stress in lung disease
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 170018
DO 10.1183/16000617.0018-2017
VO 26
IS 144
A1 Marciniak, Stefan J.
YR 2017
UL http://err.ersjournals.com/content/26/144/170018.abstract
AB Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease.Endoplasmic reticulum stress may play a role in pathogenesis of pulmonary fibrosis and cancer http://ow.ly/Ys5k30bRmL5