PT  - JOURNAL ARTICLE
AU  - Marciniak, Stefan J.
TI  - Endoplasmic reticulum stress in lung disease
AID  - 10.1183/16000617.0018-2017
DP  - 2017 Jun 30
TA  - European Respiratory Review
PG  - 170018
VI  - 26
IP  - 144
4099  - http://err.ersjournals.com/content/26/144/170018.short
4100  - http://err.ersjournals.com/content/26/144/170018.full
SO  - EUROPEAN RESPIRATORY REVIEW2017 Jun 30; 26
AB  - Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease.Endoplasmic reticulum stress may play a role in pathogenesis of pulmonary fibrosis and cancer http://ow.ly/Ys5k30bRmL5