RT Journal Article
SR Electronic
T1 Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 170007
DO 10.1183/16000617.0007-2017
VO 26
IS 144
A1 Bubendorf, Lukas
A1 Lantuejoul, Sylvie
A1 de Langen, Adrianus J.
A1 Thunnissen, Erik
YR 2017
UL http://err.ersjournals.com/content/26/144/170007.abstract
AB The pathological and molecular classification of lung cancer has become substantially more complex over the past decade. For diagnostic purposes on small samples, additional stains are frequently required to distinguish between squamous cell carcinoma and adenocarcinoma. Subsequently, for advanced nonsquamous cell nonsmall cell lung carcinoma (NSCLC) patients, predictive analyses on epidermal growth factor receptor, anaplastic lymphoma kinase and ROS1 are required. In NSCLCs negative for these biomarkers, programmed death ligand-1 immunohistochemistry is performed. Small samples (biopsy and cytology) require “tissue” management, which is best achieved by the interaction of all physicians involved.Tissue management is required to perform diagnostic and predictive testing in nonsmall cell lung carcinoma http://ow.ly/Ogeq30adDvN