RT Journal Article
SR Electronic
T1 Epithelial cell migration as a potential therapeutic target in early lung cancer
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 160069
DO 10.1183/16000617.0069-2016
VO 26
IS 143
A1 Fraser R. Millar
A1 Sam M. Janes
A1 Adam Giangreco
YR 2017
UL http://err.ersjournals.com/content/26/143/160069.abstract
AB Lung cancer is the most lethal cancer type worldwide, with the majority of patients presenting with advanced stage disease. Targeting early stage disease pathogenesis would allow dramatic improvements in lung cancer patient survival. Recently, cell migration has been shown to be an integral process in early lung cancer ontogeny, with preinvasive lung cancer cells shown to migrate across normal epithelium prior to developing into invasive disease. TP53 mutations are the most abundant mutations in human nonsmall cell lung cancers and have been shown to increase cell migration via regulation of Rho-GTPase protein activity. In this review, we explore the possibility of targeting TP53-mediated Rho-GTPase activity in early lung cancer and the opportunities for translating this preclinical research into effective therapies for early stage lung cancer patients.Preinvasive lung cancer cell migration is a potential novel therapeutic target in early lung cancer http://ow.ly/FJGm305JxMQ