TY - JOUR T1 - Epithelial cell migration as a potential therapeutic target in early lung cancer JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0069-2016 VL - 26 IS - 143 SP - 160069 AU - Fraser R. Millar AU - Sam M. Janes AU - Adam Giangreco Y1 - 2017/03/31 UR - http://err.ersjournals.com/content/26/143/160069.abstract N2 - Lung cancer is the most lethal cancer type worldwide, with the majority of patients presenting with advanced stage disease. Targeting early stage disease pathogenesis would allow dramatic improvements in lung cancer patient survival. Recently, cell migration has been shown to be an integral process in early lung cancer ontogeny, with preinvasive lung cancer cells shown to migrate across normal epithelium prior to developing into invasive disease. TP53 mutations are the most abundant mutations in human nonsmall cell lung cancers and have been shown to increase cell migration via regulation of Rho-GTPase protein activity. In this review, we explore the possibility of targeting TP53-mediated Rho-GTPase activity in early lung cancer and the opportunities for translating this preclinical research into effective therapies for early stage lung cancer patients.Preinvasive lung cancer cell migration is a potential novel therapeutic target in early lung cancer http://ow.ly/FJGm305JxMQ ER -