RT Journal Article
SR Electronic
T1 Diagnosis of primary ciliary dyskinesia: potential options for resource-limited countries
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 160058
DO 10.1183/16000617.0058-2016
VO 26
IS 143
A1 Nisreen Rumman
A1 Claire Jackson
A1 Samuel Collins
A1 Patricia Goggin
A1 Janice Coles
A1 Jane S. Lucas
YR 2017
UL http://err.ersjournals.com/content/26/143/160058.abstract
AB Primary ciliary dyskinesia is a genetic disease of ciliary function leading to chronic upper and lower respiratory tract symptoms. The diagnosis is frequently overlooked because the symptoms are nonspecific and the knowledge about the disease in the primary care setting is poor. Additionally, none of the available tests is accurate enough to be used in isolation. These tests are expensive, and need sophisticated equipment and expertise to analyse and interpret results; diagnosis is therefore only available at highly specialised centres. The diagnosis is particularly challenging in countries with limited resources due to the lack of such costly equipment and expertise.In this review, we discuss the importance of early and accurate diagnosis especially for countries where the disease is clinically prevalent but diagnostic tests are lacking. We review the diagnostic tests available in specialised centres (nasal nitric oxide, high-speed video microscopy, transmission electron microscopy, immunofluorescence and genetics). We then consider modifications that might be considered in less well-resourced countries whilst maintaining acceptable accuracy.PCD diagnosis with limited resources http://ow.ly/eYN7302Y2wg