RT Journal Article
SR Electronic
T1 Bronchial epithelium in children: a key player in asthma
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 158
OP 169
DO 10.1183/16000617.0101-2015
VO 25
IS 140
A1 Ania Carsin
A1 Julie Mazenq
A1 Alexandra Ilstad
A1 Jean-Christophe Dubus
A1 Pascal Chanez
A1 Delphine Gras
YR 2016
UL http://err.ersjournals.com/content/25/140/158.abstract
AB Bronchial epithelium is a key element of the respiratory airways. It constitutes the interface between the environment and the host. It is a physical barrier with many chemical and immunological properties. The bronchial epithelium is abnormal in asthma, even in children. It represents a key component promoting airway inflammation and remodelling that can lead to chronic symptoms. In this review, we present an overview of bronchial epithelium and how to study it, with a specific focus on children. We report physical, chemical and immunological properties from ex vivo and in vitro studies. The responses to various deleterious agents, such as viruses or allergens, may lead to persistent abnormalities orchestrated by bronchial epithelial cells. As epithelium dysfunctions occur early in asthma, reprogramming the epithelium may represent an ambitious goal to induce asthma remission in children.Bronchial epithelium is a morphological and functional dysregulated gatekeeper in asthmatic children http://ow.ly/Y4MaM