RT Journal Article
SR Electronic
T1 Therapeutic strategies in pneumonia: going beyond antibiotics
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 516
OP 524
DO 10.1183/16000617.0034-2015
VO 24
IS 137
A1 Holger Müller-Redetzky
A1 Jasmin Lienau
A1 Norbert Suttorp
A1 Martin Witzenrath
YR 2015
UL http://err.ersjournals.com/content/24/137/516.abstract
AB Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therapeutic targets have been identified and numerous innovative therapeutic approaches demonstrated to improve lung injury in experimental preclinical studies. However, at present specific preventive or curative strategies for the treatment of lung failure in pneumonia in addition to antibiotics are still missing. The aim of this mini-review is to give a short overview of some, but not all, adjuvant therapeutic strategies for pneumonia and its most important complications, sepsis and acute respiratory distress syndrome, and briefly discuss future perspectives.A review of preclinical and clinical research on adjuvant therapies for pneumonia http://ow.ly/OeiN3