TY - JOUR T1 - An official American Thoracic Society/European Respiratory Society statement: research questions in COPD JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 159 LP - 172 DO - 10.1183/16000617.00000315 VL - 24 IS - 136 AU - Bartolome R. Celli AU - Marc Decramer AU - Jadwiga A. Wedzicha AU - Kevin C. Wilson AU - Alvar A. Agustí AU - Gerard J. Criner AU - William MacNee AU - Barry J. Make AU - Stephen I. Rennard AU - Robert A. Stockley AU - Claus Vogelmeier AU - Antonio Anzueto AU - David H. Au AU - Peter J. Barnes AU - Pierre-Regis Burgel AU - Peter M. Calverley AU - Ciro Casanova AU - Enrico M. Clini AU - Christopher B. Cooper AU - Harvey O. Coxson AU - Daniel J. Dusser AU - Leonardo M. Fabbri AU - Bonnie Fahy AU - Gary T. Ferguson AU - Andrew Fisher AU - Monica J. Fletcher AU - Maurice Hayot AU - John R. Hurst AU - Paul W. Jones AU - Donald A. Mahler AU - François Maltais AU - David M. Mannino AU - Fernando J. Martinez AU - Marc Miravitlles AU - Paula M. Meek AU - Alberto Papi AU - Klaus F. Rabe AU - Nicolas Roche AU - Frank C. Sciurba AU - Sanjay Sethi AU - Nikos Siafakas AU - Don D. Sin AU - Joan B. Soriano AU - James K. Stoller AU - Donald P. Tashkin AU - Thierry Troosters AU - Geert M. Verleden AU - Johny Verschakelen AU - Jorgen Vestbo AU - John W. Walsh AU - George R. Washko AU - Robert A. Wise AU - Emiel F.M. Wouters AU - Richard L. ZuWallack Y1 - 2015/06/01 UR - http://err.ersjournals.com/content/24/136/159.abstract N2 - Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality and resource use worldwide. The goal of this official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Clinicians, researchers and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarised, and then salient knowledge gaps were identified. Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Great strides have been made in the diagnosis, assessment and management of COPD, as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS research statement highlights the types of research that leading clinicians, researchers and patient advocates believe will have the greatest impact on patient-centred outcomes. ATS/ERS statement highlighting research areas that will have the greatest impact on patient-centred outcomes in COPD http://ow.ly/LXW2J ER -