RT Journal Article SR Electronic T1 Comorbidities of COPD JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 454 OP 475 DO 10.1183/09059180.00008612 VO 22 IS 130 A1 Arnaud Cavaillès A1 Graziella Brinchault-Rabin A1 Adrien Dixmier A1 François Goupil A1 Christophe Gut-Gobert A1 Sylvain Marchand-Adam A1 Jean-Claude Meurice A1 Hugues Morel A1 Christine Person-Tacnet A1 Christophe Leroyer A1 Patrice Diot YR 2013 UL http://err.ersjournals.com/content/22/130/454.abstract AB By 2020, chronic obstructive pulmonary disease (COPD) will be the third cause of mortality. Extrapulmonary comorbidities influence the prognosis of patients with COPD. Tobacco smoking is a common risk factor for many comorbidities, including coronary heart disease, heart failure and lung cancer. Comorbidities such as pulmonary artery disease and malnutrition are directly caused by COPD, whereas others, such as systemic venous thromboembolism, anxiety, depression, osteoporosis, obesity, metabolic syndrome, diabetes, sleep disturbance and anaemia, have no evident physiopathological relationship with COPD. The common ground between most of these extrapulmonary manifestations is chronic systemic inflammation. All of these diseases potentiate the morbidity of COPD, leading to increased hospitalisations and healthcare costs. They can frequently cause death, independently of respiratory failure. Comorbidities make the management of COPD difficult and need to be evaluated and treated adequately.