PT  - JOURNAL ARTICLE
AU  - Arnaud Cavaillès
AU  - Graziella Brinchault-Rabin
AU  - Adrien Dixmier
AU  - François Goupil
AU  - Christophe Gut-Gobert
AU  - Sylvain Marchand-Adam
AU  - Jean-Claude Meurice
AU  - Hugues Morel
AU  - Christine Person-Tacnet
AU  - Christophe Leroyer
AU  - Patrice Diot
TI  - Comorbidities of COPD
AID  - 10.1183/09059180.00008612
DP  - 2013 Dec 01
TA  - European Respiratory Review
PG  - 454--475
VI  - 22
IP  - 130
4099  - http://err.ersjournals.com/content/22/130/454.short
4100  - http://err.ersjournals.com/content/22/130/454.full
SO  - EUROPEAN RESPIRATORY REVIEW2013 Dec 01; 22
AB  - By 2020, chronic obstructive pulmonary disease (COPD) will be the third cause of mortality. Extrapulmonary comorbidities influence the prognosis of patients with COPD. Tobacco smoking is a common risk factor for many comorbidities, including coronary heart disease, heart failure and lung cancer. Comorbidities such as pulmonary artery disease and malnutrition are directly caused by COPD, whereas others, such as systemic venous thromboembolism, anxiety, depression, osteoporosis, obesity, metabolic syndrome, diabetes, sleep disturbance and anaemia, have no evident physiopathological relationship with COPD. The common ground between most of these extrapulmonary manifestations is chronic systemic inflammation. All of these diseases potentiate the morbidity of COPD, leading to increased hospitalisations and healthcare costs. They can frequently cause death, independently of respiratory failure. Comorbidities make the management of COPD difficult and need to be evaluated and treated adequately.