RT Journal Article SR Electronic T1 Lymphangioleiomyomatosis: what do we know and what are we looking for? JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 034 OP 044 DO 10.1183/09059180.00011010 VO 20 IS 119 A1 S. Harari A1 O. Torre A1 J. Moss YR 2011 UL http://err.ersjournals.com/content/20/119/034.abstract AB Lymphangioleiomyomatosis (LAM) is a rare disease characterised by proliferation of abnormal smooth muscle-like cells (LAM cells) leading to progressive cystic destruction of the lung, lymphatic abnormalities and abdominal tumours. It affects predominantly females and can occur sporadically or in patients with tuberous sclerosis complex. This review describes the recent progress in our understanding of the molecular pathogenesis of the disease and LAM cell biology. It also summarises current therapeutic approaches and the most promising areas of research for future therapeutic strategies.