TY - JOUR T1 - Innate immunity is a key factor for the resolution of inflammation in asthma JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 141 LP - 153 DO - 10.1183/09059180.00012514 VL - 24 IS - 135 AU - Cindy Barnig AU - Bruce D. Levy Y1 - 2015/03/01 UR - http://err.ersjournals.com/content/24/135/141.abstract N2 - The resolution of inflammation is an integral and natural part of the physiological response to tissue injury, infection and allergens or other noxious stimuli. Resolution is now recognised as an active process with highly regulated cellular and biochemical events. Recent discoveries have highlighted that innate inflammatory cells have bimodal effector functions during the inflammatory response, including active roles during the resolution process. Several mediators displaying potent pro-resolving actions have recently been uncovered. Lipoxin A4, the lead member of this new class of pro-resolving mediators, has anti-inflammatory actions on type 2 innate lymphoid cells and pro-resolving actions through natural killer cells in asthma immunobiology. Eosinophils are also able to control crucial aspects of resolution through the generation of pro-resolving mediators. Uncontrolled asthma has been associated with a defect in the generation of specialised pro-resolving mediators, including lipoxin A4 and protectin D1. Thus, bioactive stable analogue mimetics of these mediators that can harness endogenous resolution mechanisms for inflammation may offer new therapeutic strategies for asthma and airway inflammation associated diseases. Innate inflammatory cells control crucial aspects of resolution of the inflammatory response in asthma http://ow.ly/Hj0yl ER -