RT Journal Article
SR Electronic
T1 Severe refractory asthma: an update
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 227
OP 235
DO 10.1183/09059180.00001913
VO 22
IS 129
A1 Reinier R.L. Wener
A1 Elisabeth H. Bel
YR 2013
UL http://err.ersjournals.com/content/22/129/227.abstract
AB Asthma is a heterogeneous disease in which adequate asthma control cannot be achieved in a substantial proportion despite currently available treatment possibilities. This subgroup has been defined as “severe refractory” asthma. Over the past years considerable progress has been made regarding a more exact definition of severe refractory asthma. A systematic approach to evaluate the asthma patient has been postulated. Further detailed classification into distinct phenotypes is ongoing to target the right treatment to the right patient. And, new therapeutic targeted treatment options are currently in development to provide possible new targets to improve disease state, symptoms and quality of life. This review will provide an update on the latest advancements with regard to all these domains.