TY - JOUR T1 - Severe refractory asthma: an update JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 227 LP - 235 DO - 10.1183/09059180.00001913 VL - 22 IS - 129 AU - Reinier R.L. Wener AU - Elisabeth H. Bel Y1 - 2013/09/01 UR - http://err.ersjournals.com/content/22/129/227.abstract N2 - Asthma is a heterogeneous disease in which adequate asthma control cannot be achieved in a substantial proportion despite currently available treatment possibilities. This subgroup has been defined as “severe refractory” asthma. Over the past years considerable progress has been made regarding a more exact definition of severe refractory asthma. A systematic approach to evaluate the asthma patient has been postulated. Further detailed classification into distinct phenotypes is ongoing to target the right treatment to the right patient. And, new therapeutic targeted treatment options are currently in development to provide possible new targets to improve disease state, symptoms and quality of life. This review will provide an update on the latest advancements with regard to all these domains. ER -