PT - JOURNAL ARTICLE AU - M. Pallayova AU - V. Donic AU - V. Donicova AU - Z. Tomori AU - S. Gresova TI - The effect of continuous positive airway pressure on glucose excursions in diabetics with sleep-disordered breathing: the results of continuous glucose monitoring AID - 10.1183/09059180.00010123 DP - 2006 Dec 01 TA - European Respiratory Review PG - 218--220 VI - 15 IP - 101 4099 - http://err.ersjournals.com/content/15/101/218.short 4100 - http://err.ersjournals.com/content/15/101/218.full SO - EUROPEAN RESPIRATORY REVIEW2006 Dec 01; 15 AB - Sleep-disordered breathing (SDB) is often associated with impaired glucose metabolism. The study aimed at assessing immediate effect of CPAP on glucose excursions in type 2 diabetic patients with SDB measured with 72-hour continuous glucose monitoring system (CGMS). 8 type 2 diabetic patients with SDB (men, age 48,13±4,91 years, BMI 34,06±7,41 kg·m−2, HbA1c 7,3±1,4%) underwent 2 overnight polysomnographic examinations including diagnostic night and CPAP night. CGMS was applied on both occasions. Statistical analyses included paired Student's t-test. CPAP decreased apnoea-hypopnoea index (AHI) from 57,64±9,64·h−1 to 8,05±4,42·h−1 (p<0,0001) with significant improvement of saturation. Frequent episodes of sleep apnoea/hypopnoea and severe oxygen desaturation were followed by significant rise in blood glucose of up to 12,3 mmol·l−1. Duration of post-hypoxic hyperglycemia was 50±10,79 min and its climax tended to be appeared up to 45min post-hypoxia. Nocturnal hyperglycemia strongly correlated with severe oxygen desaturation. Nocturnal glucose values were significantly higher during diagnostic night than during CPAP night (8,19±0,99 mmol·l−1 versus 6,77±1,47 mmol·l−1; p<0,0001). CGMS also showed improved preprandial and 1,5-hour postprandial glucose levels for breakfast after CPAP night. The improvement in overall glucose levels was much greater in patients with BMI<30 kg·m−2 than in more obese patients. The results suggest that nocturnal hyperglycemia is closely related to desaturation and CPAP treatment may have an immediate decreasing effect on blood glucose in type 2 diabetic patients with SDB.