TY - JOUR T1 - Current concepts: host–pathogen interactions in cystic fibrosis airways disease JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 320 LP - 332 DO - 10.1183/09059180.00006113 VL - 23 IS - 133 AU - Anthony C. Tang AU - Stuart E. Turvey AU - Marco P. Alves AU - Nicolas Regamey AU - Burkhard Tümmler AU - Dominik Hartl Y1 - 2014/09/01 UR - http://err.ersjournals.com/content/23/133/320.abstract N2 - Chronic infection and inflammation are defining characteristics of cystic fibrosis (CF) airway disease. Conditions within the airways of patients living with CF are conducive to colonisation by a variety of opportunistic bacterial, viral and fungal pathogens. Improved molecular identification of microorganisms has begun to emphasise the polymicrobial nature of infections in the CF airway microenvironment. Changes to CF airway physiology through loss of cystic fibrosis transmembrane conductance regulator functionality result in a wide range of immune dysfunctions, which permit pathogen colonisation and persistence. This review will summarise the current understanding of how CF pathogens infect, interact with and evade the CF host. ER -