RT Journal Article
SR Electronic
T1 Current concepts: host–pathogen interactions in cystic fibrosis airways disease
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 320
OP 332
DO 10.1183/09059180.00006113
VO 23
IS 133
A1 Tang, Anthony C.
A1 Turvey, Stuart E.
A1 Alves, Marco P.
A1 Regamey, Nicolas
A1 Tümmler, Burkhard
A1 Hartl, Dominik
YR 2014
UL http://err.ersjournals.com/content/23/133/320.abstract
AB Chronic infection and inflammation are defining characteristics of cystic fibrosis (CF) airway disease. Conditions within the airways of patients living with CF are conducive to colonisation by a variety of opportunistic bacterial, viral and fungal pathogens. Improved molecular identification of microorganisms has begun to emphasise the polymicrobial nature of infections in the CF airway microenvironment. Changes to CF airway physiology through loss of cystic fibrosis transmembrane conductance regulator functionality result in a wide range of immune dysfunctions, which permit pathogen colonisation and persistence. This review will summarise the current understanding of how CF pathogens infect, interact with and evade the CF host.