PT  - JOURNAL ARTICLE
AU  - Anthony C. Tang
AU  - Stuart E. Turvey
AU  - Marco P. Alves
AU  - Nicolas Regamey
AU  - Burkhard Tümmler
AU  - Dominik Hartl
TI  - Current concepts: host–pathogen interactions in cystic fibrosis airways disease
AID  - 10.1183/09059180.00006113
DP  - 2014 Sep 01
TA  - European Respiratory Review
PG  - 320--332
VI  - 23
IP  - 133
4099  - http://err.ersjournals.com/content/23/133/320.short
4100  - http://err.ersjournals.com/content/23/133/320.full
SO  - EUROPEAN RESPIRATORY REVIEW2014 Sep 01; 23
AB  - Chronic infection and inflammation are defining characteristics of cystic fibrosis (CF) airway disease. Conditions within the airways of patients living with CF are conducive to colonisation by a variety of opportunistic bacterial, viral and fungal pathogens. Improved molecular identification of microorganisms has begun to emphasise the polymicrobial nature of infections in the CF airway microenvironment. Changes to CF airway physiology through loss of cystic fibrosis transmembrane conductance regulator functionality result in a wide range of immune dysfunctions, which permit pathogen colonisation and persistence. This review will summarise the current understanding of how CF pathogens infect, interact with and evade the CF host.