PT - JOURNAL ARTICLE AU - Tang, Anthony C. AU - Turvey, Stuart E. AU - Alves, Marco P. AU - Regamey, Nicolas AU - Tümmler, Burkhard AU - Hartl, Dominik TI - Current concepts: host–pathogen interactions in cystic fibrosis airways disease AID - 10.1183/09059180.00006113 DP - 2014 Sep 01 TA - European Respiratory Review PG - 320--332 VI - 23 IP - 133 4099 - http://err.ersjournals.com/content/23/133/320.short 4100 - http://err.ersjournals.com/content/23/133/320.full SO - EUROPEAN RESPIRATORY REVIEW2014 Sep 01; 23 AB - Chronic infection and inflammation are defining characteristics of cystic fibrosis (CF) airway disease. Conditions within the airways of patients living with CF are conducive to colonisation by a variety of opportunistic bacterial, viral and fungal pathogens. Improved molecular identification of microorganisms has begun to emphasise the polymicrobial nature of infections in the CF airway microenvironment. Changes to CF airway physiology through loss of cystic fibrosis transmembrane conductance regulator functionality result in a wide range of immune dysfunctions, which permit pathogen colonisation and persistence. This review will summarise the current understanding of how CF pathogens infect, interact with and evade the CF host.