@article {Deacon187, author = {SarahJ. Deacon and EmmaE. Vincent and SallyJ. Singh and MichaelC. Steiner and Paul Greenhaff and MichaelD. Morgan}, title = {Does creatine supplementation enhance the effects of physical training during pulmonary rehabilitation in COPD?}, volume = {15}, number = {101}, pages = {187--189}, year = {2006}, doi = {10.1183/09059180.00010116}, publisher = {European Respiratory Society}, abstract = {We conducted a randomised, placebo-controlled trial to examine whether creatine supplementation augments the benefits of pulmonary rehabilitation (PR), containing aerobic exercise and resistance training (RT). 80 subjects with COPD (GOLD stages I{\textendash}IV) [mean (SD) age 68 (7.8) yrs, FEV1 44.1 (20.3) \% predicted] completed 21 sessions of PR, with enhanced RT, following baseline measurements and randomisation to take creatine (Cr) or placebo (Pl) supplement. A subgroup had muscle biopsies. Groups were well matched at baseline except for gender (M:F Cr 19:19, Pl 31:11, Chi2 pā€Š=ā€Š0.03). Mean change in functional performance \& muscle strength after PR are shown. Health status (CRQ-SR) improved significantly after PR but did not differ between groups. Muscle biopsies showed evidence of creatine uptake. This adequately powered study showed significant improvements in all outcomes following PR. Creatine supplementation did not enhance these benefits.}, issn = {0905-9180}, URL = {https://err.ersjournals.com/content/15/101/187}, eprint = {https://err.ersjournals.com/content/15/101/187.full.pdf}, journal = {European Respiratory Review} }