PT  - JOURNAL ARTICLE
AU  - C. C. W. Hsia
TI  - Quantitative morphology of compensatory lung growth
AID  - 10.1183/09059180.00010105
DP  - 2006 Dec 01
TA  - European Respiratory Review
PG  - 148--156
VI  - 15
IP  - 101
4099  - http://err.ersjournals.com/content/15/101/148.short
4100  - http://err.ersjournals.com/content/15/101/148.full
SO  - EUROPEAN RESPIRATORY REVIEW2006 Dec 01; 15
AB  - Compensatory lung growth is defined by the absolute increases in the quantity of functioning lung tissue in response to injury and/or disease, leading to a positive impact on functional outcome. The pneumonectomy model is used as an example to illustrate the salient features of compensatory growth and the specific considerations in its morphological quantification, including techniques of sampling and analysis, resolution of ultrastructural details, selection of markers for measurement, and interpretation of results in the context of organ architecture and physiology. The potential for structure–function dissociation is described in the present article. The current paper will discuss the application of high-resolution computed tomography to noninvasively quantify regional anatomy as well as temporal evolution of lung growth.