TY - JOUR T1 - Disseminated nontuberculous infections with <em>Mycobacterium genavense</em> during sarcoidosis JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 299 LP - 301 DO - 10.1183/09059180.00002209 VL - 18 IS - 114 AU - H. Dumouchel-Champagne AU - C. Charlier-Woerther AU - A. Boibieux AU - M. Ffrench AU - G. Carret AU - C. Chidiac AU - D. Peyramond AU - F. Ader Y1 - 2009/12/01 UR - http://err.ersjournals.com/content/18/114/299.abstract N2 - Sarcoidosis is a chronic disease characterised by the development and accumulation of granulomas in multiple organs. We report two observations of disseminated Mycobacterium genavense infection in patients with proven sarcoidosis. High fever and abdominal pain appeared at 8 and 18 months following the initiation of immunosuppressive therapy. Abdominal computed tomography scans of the patients showed diffuse mesenteric lymphadenitis and splenomegaly. The diagnosis was obtained on bone marrow specimens for both patients with numerous acid-fast bacteria at direct examination and positive specific mycobacterial identification by nucleic acid amplification test. Despite prompt antimycobacterial therapy, occurrence of complications (peritonitis post-splenectomy surgery and lung carcinoma) resulted in a fatal outcome for both patients. These cases highlight that opportunistic infections like M. genavense or other nontuberculous mycobacterial infections should be considered for long-standing immunocompromised patients with sarcoidosis. ER -