TY - JOUR T1 - Implementing the ESC/ERS pulmonary hypertension guidelines: real-life cases from a national referral centre JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 272 LP - 290 DO - 10.1183/09059180.00005909 VL - 18 IS - 114 AU - D. Montani AU - D. S. O'Callaghan AU - X. Jaïs AU - L. Savale AU - D. Natali AU - A. Redzepi AU - S. Hoette AU - F. Parent AU - O. Sitbon AU - G. Simonneau AU - M. Humbert Y1 - 2009/12/01 UR - http://err.ersjournals.com/content/18/114/272.abstract N2 - Pulmonary hypertension (PH) comprises a heterogeneous group of disorders characterised by increased pulmonary vascular resistance that results in progressive right ventricular failure. In order to translate current evidence into routine clinical practice, the European Society of Cardiology (ESC) and the European Respiratory Society (ERS) have recently jointly proposed evidence-based guidelines for the optimal management of different PH patient groups. This article describes a series of clinical cases of PH due to various aetiologies that were referred to a large national PH expert referral centre. In each case, the assessment and therapeutic approach undertaken is described in the context of the new ECS/ERS guidelines. The routine diagnostic work-up of suspected idiopathic pulmonary arterial hypertension (PAH) and recommended treatments for patients with functional class II, III and IV disease is emphasised. Familial screening and management of heritable PAH is discussed. Appropriate investigation and therapeutic strategies for patients with chronic thromboembolic disease and PH that is associated with congenital heart disease, pulmonary veno-occlusive disease and systemic sclerosis are also highlighted. ER -