TY - JOUR T1 - The milky (path)way of proteinosis: has the time come JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 67 LP - 68 DO - 10.1183/09059180.00003011 VL - 20 IS - 120 AU - M. Luisetti Y1 - 2011/06/01 UR - http://err.ersjournals.com/content/20/120/67.abstract N2 - After having read the paper by Borie et al. [1] in this issue of European Respiratory Review, I decided not to write a classic scientific editorial.It is often difficult to write an editorial comment for a review article, and in this case even more so since the paper by Borie et al. [1] is one of the most comprehensive and up-to-date reviews on pulmonary alveolar proteinosis (PAP) since the milestone article of Seymour and Presneill [2]. What could I add or how would I comment on the achievement that lung biopsy is now no longer required to diagnose typical forms of autoimmune PAP? Or that the passive transfer of human granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies (GMAbs) to monkeys reproduces features typical of PAP, thus, supporting the pathogenic role of GMAbs [3]? Or that several surfactant-associated genes and proteins may be involved not only in proteinosis, but also in other forms of interstitial lung diseases [4]?Beyond the intrinsic value of the scientific information, the review by Borie et al. [1] also has the … ER -