Unfortunately, an error was made in labelling figure 4 of this manuscript. The solid black line should have been labelled “Fick principle” not “Fick Law”. The equation associated with this label should have read “VʹO2=CO×Pa–vO2” not “VʹO2=CO×a–vO2 PO2”. The corrected version of figure 4 is shown below.
The article has been corrected and republished online.
The Wagner diagram. Oxygen uptake is plotted as a function of microvascular oxygen pressure. Black line: diffusive (Fick law) and convective (Fick principle) components that interact to determine peak oxygen uptake (VʹO2peak). The Fick principle line is not straight because it directly represents the haemoglobin dissociation curve (greater haemoglobin O2 affinity), resulting in a lower venous O2 partial pressure [130]. The slope of the straight line (Fick law) is determined by the diffusing capacity of the muscles [130]. Red line: in patients with heart failure, a left-shifted haemoglobin dissociation curve (greater haemoglobin O2 affinity), resulting in a lower venous O2 partial pressure, and a lower slope of the Fick law line results in earlier bisection of both diffusive and convective components and reduced VʹO2peak. Pa–vO2: arterio-venous difference in partial pressure of oxygen; DO2: oxygen delivery; HFrEF: heart failure with reduced ejection fraction; PO2: partial pressure of oxygen; CO: cardiac output.
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