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Furin as a therapeutic target in cystic fibrosis airways disease

Lisa E.J. Douglas, James A. Reihill, Bethany M. Montgomery, S. Lorraine Martin
European Respiratory Review 2023 32: 220256; DOI: 10.1183/16000617.0256-2022
Lisa E.J. Douglas
School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland, UK
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James A. Reihill
School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland, UK
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Bethany M. Montgomery
School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland, UK
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S. Lorraine Martin
School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland, UK
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  • For correspondence: l.martin@qub.ac.uk
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Article Information

vol. 32 no. 168
DOI 
https://doi.org/10.1183/16000617.0256-2022
PubMed 
37137509

Published By 
European Respiratory Society
Print ISSN 
0905-9180
Online ISSN 
1600-0617
History 
  • Received December 21, 2022
  • Accepted February 22, 2023
  • Published online May 3, 2023.

Copyright & Usage 
Copyright ©The authors 2023 This version is distributed under the terms of the Creative Commons Attribution Licence 4.0.

Author Information

  1. Lisa E.J. Douglas,
  2. James A. Reihill,
  3. Bethany M. Montgomery and
  4. S. Lorraine Martin⇑
  1. School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland, UK
  1. Corresponding author: S. Lorraine Martin (l.martin{at}qub.ac.uk)
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Funding

  • Medical Research Council

    MR/W004135/1
  • Boston Pharmaceuticals

Article usage

Article usage: May 2023 to November 2023

AbstractFullPdf
May 202311774166
Jun 2023824969
Jul 202389147
Aug 2023107456
Sep 2023310251
Oct 2023610746
Nov 20231516348

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Vol 32 Issue 168 Table of Contents
European Respiratory Review: 32 (168)
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Furin as a therapeutic target in cystic fibrosis airways disease
Lisa E.J. Douglas, James A. Reihill, Bethany M. Montgomery, S. Lorraine Martin
European Respiratory Review Jun 2023, 32 (168) 220256; DOI: 10.1183/16000617.0256-2022

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Furin as a therapeutic target in cystic fibrosis airways disease
Lisa E.J. Douglas, James A. Reihill, Bethany M. Montgomery, S. Lorraine Martin
European Respiratory Review Jun 2023, 32 (168) 220256; DOI: 10.1183/16000617.0256-2022
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • CF airways disease
    • Furin in the airways
    • Furin as a regulator of the epithelial sodium channel (ENaC)
    • Other key roles for furin in CF airways disease pathogenesis
    • The therapeutic potential of furin inhibition beyond CF airways disease
    • Challenges of furin as a therapeutic target
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Subjects

  • CF and non-CF bronchiectasis
  • Pulmonary pharmacology and therapeutics
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