Skip to main content

Main menu

  • Home
  • Current issue
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions

Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis

Inês Rodrigues, Ricardo Estêvão Gomes, Lígia Maria Coutinho, Maria Teresa Rego, Firmino Machado, António Morais, Helder Novais Bastos
European Respiratory Review 2022 31: 210280; DOI: 10.1183/16000617.0280-2021
Inês Rodrigues
1Pulmonology Dept, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal
9These authors contributed equally to this work and share first authorship
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ricardo Estêvão Gomes
2Pulmonology Dept, Hospital Garcia de Orta, Almada, Portugal
9These authors contributed equally to this work and share first authorship
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lígia Maria Coutinho
3Escola de Medicina, University of Minho, Braga, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Teresa Rego
3Escola de Medicina, University of Minho, Braga, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Firmino Machado
4Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
5Centro Académico Clínico Egas Moniz Health Alliance, Aveiro, Portugal
6Faculdade de Medicina, University of Porto, Porto, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
António Morais
6Faculdade de Medicina, University of Porto, Porto, Portugal
7Pulmonology Dept, Centro Hospitalar Universitário São João, Porto, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for António Morais
Helder Novais Bastos
6Faculdade de Medicina, University of Porto, Porto, Portugal
7Pulmonology Dept, Centro Hospitalar Universitário São João, Porto, Portugal
8Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Helder Novais Bastos
  • For correspondence: hnovaisbastos@med.up.pt
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Figures

  • Tables
  • Supplementary Materials
  • FIGURE 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1

    Flowchart of study selection. ILD: interstitial lung disease; VATS: video-assisted thoracoscopic surgery.

  • FIGURE 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2

    Meta-analysis of the diagnostic yield of a) transbronchial lung cryobiopsy (TBLC) and b) video-assisted thoracoscopic surgery, according to diagnostic criteria. The diamonds indicate the pooled effects. CI: confidence interval; MDD: multidisciplinary discussion.

  • FIGURE 3
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3

    Complications related to the technique: a) moderate/severe bleeding after transbronchial lung cryobiopsy (TBLC); b) pneumothorax after TBLC and video-assisted thoracoscopic surgery (VATS). The diamonds indicate the pooled effects. CI: confidence interval.

Tables

  • Figures
  • Supplementary Materials
  • TABLE 1

    Outcomes of transbronchial lung cryobiopsy (TBLC) of the included studies

    Method of diagnosisFirst author (year) [ref.]Biopsy method (n)Diagnostic yield, %Mortality, n (%)Pneumothorax, n (%)Chest drain, n (%)Bleeding, n (%)ILD acute exacerbation, n (%)
    MildModerateSevere
    Histology
    Hernández-González (2015) [43]TBLC (33)79.0na4 (12)1 (3.0)3 (9.0)7 (21)0 (0.0)na
    Ravaglia (2016) [60]TBLC (297)82.81 (0.3)60 (20.2)46 (15.5)0 (0.0)0 (0.0)0 (0.0)1 (0.3)
    Linhas (2017) [25]TBLC (90)na0 (0.0)22 (22.4)18 (20.0)8 (8.9)5 (5.6)0 (0.0)0 (0.0)
    Lentz (2018) [47]TBLC (104)44.20 (0.0)3 (3.0)3 (3.0)100 (96.0)0 (0.0)4 (4.0)na
    Cooley (2018) [26]TBLC (159)69.00 (0.0)17 (11.0)14 (8.8)0 (0.0)6 (3.8)#na
    Hagmeyer (2019) [30]TBLC (61)82.02 (3.2)10 (16.4)nana7 (14.5)8 (13.1)2 (3.2)
    Harari (2019) [29]TBLC (73)88.0na8 (10.9)2 (2.7)6 (19.0)0 (0.0)1 (1.4)na
    Romagnoli (2019) [62]TBLC (21)81.0na2 (9.5)1 (4.8)nanana1 (4.8)
    Samitas (2019) [15]TBLC (50)80.0na5 (10.0)0 (0.0)19 (38.0)12 (24.0)0 (0.0)0 (0.0)
    Cho (2019) [24]TBLC (40)85.00 (0.0)0 (0.0)0 (0.0)36 (90.0)2 (5.0)2 (5.0)na
    Abdelghani (2019) [28]TBLC (40)92.51 (1.3)2 (5.0)2 (5.0)6 (15.0)5 (8.3)0 (0.0)na
    Hetzel (2019) [18]TBLC (359)na1 (0.3)27 (7.5)na203 (56.5)54 (15.0)4 (1.1)na
    Troy (2020) [61]TBLC (65)90.01 (2.0)1 (4.0)na14 (22.0)¶0 (0.0)2 (3.1)
    Aburto (2020) [38]TBLC (257)80.20 (0.0)5 (2.0)na18 (7.0)+1 (0.4)
    Bondue (2020) [35]TBLC (81)84.0na17 (21.0)9 (11.0)47 (58.0)25 (31.0)4 (5.0)1 (1.2)
    Koslow (2020) [34]TBLC (120)52.42 (1.6)6 (5.0)1 (0.9)na8 (7.0)#1 (0.8)
    Pajares (2020) [36]TBLC (124)54.8na3 (2.4)2 (1.6)72 (60.0)8 (6.5)1 (0.8)na
    Gnass (2020) [39]TBLC (114)79.0na5 (4.4)5 (4.4)0 (0.0)0 (0.0)0 (0.0)0 (0.0)
    Wang (2020) [37]TBLC (70)68.61 (1.4)3 (4.3)3 (4.3)0 (0.0)0 (0.0)4 (5.7)0 (0.0)
    MDD
    Fruchter (2014) [42]TBLC (75)70.0na2 (2.7)0 (0.0)3 (4.0)0 (0.0)0 (0.0)0 (0.0)
    Griff (2014) [33]TBLC (52)79.00 (0.0)0 (0.0)0 (0.0)nana0 (0.0)na
    Pajares (2014) [41]TBLC (39)51.4na3 (7.7)na12 (30.8)22 (56.4)0 (0.0)0 (0.0)
    Hernández-González (2015) [43]TBLC (33)79.0na4 (12)1 (3.0)3 (9.0)7 (21)0 (0.0)na
    Cascante (2016) [46]TBLC (55)87.30 (0.0)8 (14.5)7 (12.7)4 (7.3)1 (1.8)1 (1.8)na
    Ramaswamy (2016) [45]TBLC (56)66.0na11 (20)nanana1 (2.0)0 (0.0)
    Kronborg-White (2017) [44]TBLC (38)74.0na10 (26)8 (21.0)na6 (15.0)1 (3.0)0 (0.0)
    Bango-Álvarez (2017) [23]TBLC (106)86.00 (0.0)5 (4.7)2 (1.9)89 (84.0)17 (16)0 (0.0)0 (0.0)
    Lentz (2018) [47]TBLC (104)68.30 (0.0)3 (3.0)3 (3.0)100 (96.0)0 (0.0)4 (4.0)na
    Cooley (2018) [26]TBLC (159)79.00 (0.0)17 (11.0)14 (8.8)0 (0.0)6 (3.8)#na
    Dhooria (2018) [27]TBLC (128)78.14 (3.1)14 (10.9)11 (8.6)13 (10.2)4 (3.1)3 (2.3)3 (2.3)
    Hagmeyer (2019) [30]TBLC (61)75.02 (3.2)10 (16.4)nana7 (14.5)8 (13.1)2 (3.2)
    Harari (2019) [29]TBLC (73)94.5na8 (10.9)2 (2.7)6 (19.0)0 (0.0)1 (1.4)na
    Romagnoli (2019) [62]TBLC (21)42.9na2 (9.5)1 (4.8)nanana1 (4.8)
    Samitas (2019) [15]TBLC (50)76.0na5 (10.0)0 (0.0)19 (38.0)12 (24.0)0 (0.0)0 (0.0)
    Shafiek (2019) [32]TBLC (12)83.3na0 (0.0)0 (0.0)1 (8.3)0 (0.0)0 (0.0)na
    Çirak (2020) [31]TBLC (82)91.5na6 (7.3)0 (0.0)23 (28.4)15 (18.3)1 (1.21)na
    Troy (2020) [61]TBLC (65)60.01 (2.0)1 (4.0)na14 (22.0)¶0 (0.0)2 (3.1)
    Aburto (2020) [38]TBLC (257)90.30 (0.0)5 (2.0)na18 (7.0)+1 (0.4)
    Bondue (2020) [35]TBLC (81)74.0na17 (21.0)9 (11.0)47 (58.0)25 (31.0)4 (5.0)1 (1.2)
    Hussein (2020) [40]TBLC (23)95.60 (0.0)2 (8.7)1 (4.3)0 (0.0)0 (0.0)1 (4.4)0 (0.0)
    Koslow (2020) [34]TBLC (120)55.02 (1.6)6 (5.0)1 (0.9)na8 (7.0)#1 (0.8)
    Pajares (2020) [36]TBLC (124)47.6na3 (2.4)2 (1.6)72 (60.00)8 (6.5)1 (0.8)na

    ILD: interstitial lung disease; MDD: multidisciplinary discussion; na: not available. #: classified as moderate/severe; ¶: classified as mild/moderate; +: bleeding not classified by severity.

    • TABLE 2

      Outcomes of video-assisted thoracoscopic surgery (VATS) of the included studies

      Method of diagnosisFirst author (year) [ref.]Biopsy method (n)Diagnostic yield, %Mortality, n (%)Pneumothorax, n (%)Prolonged air leak, n (%)Pneumonia/empyema, n (%)Haemothorax, n (%)Thoracic pain, n (%)ILD acute exacerbation, n (%)
      Histology
      Kayatta (2013) [53]VATS (196)10013 (6.7)nananananana
      Pompeo (2013) [48]VATS (30)97nana0 (0.0)nanana0 (0.0)
      Morris (2014) [54]VATS (66)74.21 (1.5)7 (10.6)1 (1.5)4 (6.1)0 (0.0)3 (4.5)na
      Bagheri (2015) [55]VATS (38)94.7nana5 (13.1)nananana
      Ravaglia (2016) [60]VATS (150)98.74 (2.7)na5 (3.3)3 (2.0)nana5 (3.3)
      Jeon (2018) [59]VATS (35)1000 (0.0)na0 (0.0)0 (0.0)0 (0.0)na0 (0.0)
      Romagnoli (2019) [62]VATS (21)57.1nanananananana
      Cherchi (2020) [51]VATS (99)981 (1.0)nananananana
      MDD
      Fibla (2012) [2]VATS (224)87na6 (2.7)2 (0.9)0 (0.0)1 (0.4)8 (3.7)0 (0.0)
      Luo (2013) [52]VATS (32)1000 (0.0)8 (25.0)na18 (56.3)1 (3.1)na0 (0.0)
      Kayatta (2013) [53]VATS (196)88.613 (6.7)nananananana
      Morris (2014) [54]VATS (66)90.51 (1.5)7 (10.6)1 (1.5)4 (6.1)0 (0.0)3 (4.5)na
      Samejima (2015) [56]VATS (285)84.90 (0.0)11 (3.9)2 (0.7)0 (0.0)0 (0.0)na3 (1.0)
      Khalil (2016) [57]VATS (115)1000 (0.0)na0 (0.0)nanana1 (0.8)
      Lieberman (2017) [58]VATS (45)
      OLB (2)
      1001 (2.1)5 (10.6)nanana1 (2.1)na
      Sugino (2019) [49]VATS (143)1000 (0.0)5 (3.5)4 (2.8)nanana2 (1.4)
      Troy (2020) [61]VATS (65)741 (2.0)nananana1 (2.0)2 (3.1)
      Pastre (2021) [50]VATS (268)944 (1.5)2 (0.7)1 (0.4)2 (0.7)1 (0.4)na7 (2.6)

      ILD: interstitial lung disease; MDD: multidisciplinary discussion; na: not available; OLB: open lung biopsy.

      Supplementary Materials

      • Figures
      • Tables
      • Supplementary Material

        Please note: supplementary material is not edited by the Editorial Office, and is uploaded as it has been supplied by the author.

        Supplementary material ERR-0280-2021.SUPPLEMENT

      PreviousNext
      Back to top
      View this article with LENS
      Vol 31 Issue 166 Table of Contents
      European Respiratory Review: 31 (166)
      • Table of Contents
      • Index by author
      Email

      Thank you for your interest in spreading the word on European Respiratory Society .

      NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

      Enter multiple addresses on separate lines or separate them with commas.
      Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis
      (Your Name) has sent you a message from European Respiratory Society
      (Your Name) thought you would like to see the European Respiratory Society web site.
      CAPTCHA
      This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
      Print
      Citation Tools
      Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis
      Inês Rodrigues, Ricardo Estêvão Gomes, Lígia Maria Coutinho, Maria Teresa Rego, Firmino Machado, António Morais, Helder Novais Bastos
      European Respiratory Review Dec 2022, 31 (166) 210280; DOI: 10.1183/16000617.0280-2021

      Citation Manager Formats

      • BibTeX
      • Bookends
      • EasyBib
      • EndNote (tagged)
      • EndNote 8 (xml)
      • Medlars
      • Mendeley
      • Papers
      • RefWorks Tagged
      • Ref Manager
      • RIS
      • Zotero

      Share
      Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis
      Inês Rodrigues, Ricardo Estêvão Gomes, Lígia Maria Coutinho, Maria Teresa Rego, Firmino Machado, António Morais, Helder Novais Bastos
      European Respiratory Review Dec 2022, 31 (166) 210280; DOI: 10.1183/16000617.0280-2021
      del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
      Full Text (PDF)

      Jump To

      • Article
        • Abstract
        • Abstract
        • Background
        • Methods
        • Results
        • Discussion
        • Conclusion
        • Supplementary material
        • Footnotes
        • References
      • Figures & Data
      • Info & Metrics
      • PDF

      Subjects

      • Interstitial and orphan lung disease
      • Respiratory clinical practice
      • Tweet Widget
      • Facebook Like
      • Google Plus One

      More in this TOC Section

      • Efficacy and safety of gefapixant for chronic cough
      • Phenotype overlap in the natural history of asthma
      • Furin as a therapeutic target in CF airways disease
      Show more Reviews

      Related Articles

      Navigate

      • Home
      • Current issue
      • Archive

      About the ERR

      • Journal information
      • Editorial board
      • Press
      • Permissions and reprints
      • Advertising
      • Sponsorship

      The European Respiratory Society

      • Society home
      • myERS
      • Privacy policy
      • Accessibility

      ERS publications

      • European Respiratory Journal
      • ERJ Open Research
      • European Respiratory Review
      • Breathe
      • ERS books online
      • ERS Bookshop

      Help

      • Feedback

      For authors

      • Instructions for authors
      • Publication ethics and malpractice
      • Submit a manuscript

      For readers

      • Alerts
      • Subjects
      • RSS

      Subscriptions

      • Accessing the ERS publications

      Contact us

      European Respiratory Society
      442 Glossop Road
      Sheffield S10 2PX
      United Kingdom
      Tel: +44 114 2672860
      Email: journals@ersnet.org

      ISSN

      Print ISSN: 0905-9180
      Online ISSN: 1600-0617

      Copyright © 2023 by the European Respiratory Society