Skip to main content

Main menu

  • Home
  • Current issue
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions

Lung cancer occurrence after an episode of tuberculosis: a systematic review and meta-analysis

Javier Cabrera-Sanchez, Vicente Cuba, Victor Vega, Patrick Van der Stuyft, Larissa Otero
European Respiratory Review 2022 31: 220025; DOI: 10.1183/16000617.0025-2022
Javier Cabrera-Sanchez
1Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Javier Cabrera-Sanchez
  • For correspondence: javier.cabrera@upch.pe
Vicente Cuba
1Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Victor Vega
2Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patrick Van der Stuyft
3Dept of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Larissa Otero
1Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru
2Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Figures

  • Tables
  • Supplementary Materials
  • FIGURE 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1

    Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 flowchart. LILACS: Latin American and Caribbean Health Sciences Literature; SciELO: Scientific Electronic Library Online.

  • FIGURE 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2

    Forest plots showing the association between tuberculosis and subsequent lung cancer diagnosis in studies with adjustment for age and any assessment of smoking (model 2). HR: hazard ratio.

  • FIGURE 3
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3

    Forest plots showing the association between tuberculosis and subsequent lung cancer diagnosis in studies with adjustment for age and quantitatively assessed smoking (model 3). HR: hazard ratio.

Tables

  • Figures
  • Supplementary Materials
  • TABLE 1

    Pooled estimates of the association between tuberculosis and subsequent lung cancer diagnosis or mortality

    Model 1#Model 2¶Model 3+
    Studies nPooled estimate§ (95% CI)Studies nPooled estimate§ (95% CI)Studies nPooled estimate§ (95% CI)
    Cohort studies
     Lung cancer diagnosis8ƒ2.96 (2.28–3.83)71.77 (1.41–2.22)51.51 (1.30–1.76)
      AdenocarcinomaNA32.00 (0.93–4.31)32.00 (0.93–4.31)
      Small cell carcinomaNA30.88 (0.34–2.26)30.88 (0.34–2.26)
      Squamous cell carcinomaNA32.01 (1.00–4.03)32.01 (1.00–4.03)
     Lung cancer mortality72.97 (2.14–4.11)21.62 (1.18–2.21)NA
    Case–control studies
     Lung cancer diagnosis412.00 (1.65–2.41)231.76 (1.41–2.19)191.74 (1.42–2.13)
      Adenocarcinoma102.27 (1.46–3.52)81.96 (1.20–3.21)61.51 (0.92–2.48)
      Small cell carcinoma42.26 (1.13–4.52)31.50 (0.95–2.39)22.05 (0.42–10.03)
      Squamous cell carcinoma34.51 (2.75–7.39)42.43 (1.34–4.41)32.23 (0.85–5.86)
     Lung cancer mortality12.86 (1.87–4.45)NANA

    NA: not applicable (no study reporting this estimate). #: unadjusted estimates of lung cancer and previous tuberculosis; ¶: adjusted for age and any assessment of smoking; +: adjusted for age and quantitatively assessed smoking; §: hazard ratio for cohort studies and odds ratio for case–control studies; ƒ: studies from Taiwan used the same database and duplication of information was possible, so we considered only the cohort with the largest sample size [14].

    • TABLE 2

      Stratified pooled analysis of the association between tuberculosis and subsequent lung cancer diagnosis

      Model 1#Model 2¶Model 3+
      Studies nPooled estimate§ (95% CI)Studies nPooled estimate§ (95% CI)Studies nPooled estimate§ (95% CI)
      Cohort studies
       Risk of biasƒ
        Low42.27 (1.58–3.26)42.16 (1.35–3.44)31.72 (1.25–2.38)
        Moderate73.68 (2.57–5.27)21.38 (1.31–1.46)11.38 (1.31–1.46)
        High15.86 (3.03–11.37)11.00 (0.65–1.54)11.00 (0.65–1.54)
       Sex
        Male41.95 (1.43–2.67)21.59 (1.12–2.26)21.59 (1.12–2.26)
        Female32.37 (1.92–2.92)11.49 (1.28–1.74)11.49 (1.28–1.74)
       Smoking statusƒ
        Never-smokers12.45 (2.21–2.72)21.69 (1.21–2.38)21.69 (1.21–2.38)
       Latency periodƒ
        Up to 1 year112.5 (7.17–21.73)28.50 (4.09–17.67)28.50 (4.09–17.67)
        Up to 2 yearsNA25.01 (3.64–6.89)25.01 (3.64–6.89)
        Up to 5 years27.69 (4.79–12.34)NANA
        ≥2 yearsNA21.44 (1.06–1.96)21.44 (1.06–1.96)
        ≥4 yearsNA20.82 (0.53–1.26)20.82 (0.53–1.26)
        ≥5 years22.36 (0.90–6.19)NANA
        ≥7 years21.61 (0.88–2.95)11.69 (0.62–4.65)11.69 (0.62–4.65)
        ≥10 yearsNA21.15 (0.40–3.29)21.15 (0.40–3.29)
      Case–control studies
       Risk of biasƒ
        Low51.92 (0.82–4.51)20.91 (0.79–1.04)10.96 (0.62–1.48)
        Moderate151.89 (1.38–2.58)101.94 (1.48–2.55)101.94 (1.48–2.55)
        High212.18 (1.83–2.59)111.87 (1.47–2.39)81.48 (1.16–1.87)
       Sex
        Male102.34 (1.81–3.03)62.07 (1.57–2.71)51.87 (1.31–2.66)
        Female232.04 (1.67–2.50)131.84 (1.49–2.29)111.78 (1.39–2.28)
       Smoking statusƒ
        Never-smokers181.69 (1.20–2.36)131.90 (1.51–2.39)131.90 (1.51–2.39)
       Latency periodƒ
        1–5 yearsNA27.20 (0.52–99.19)27.20 (0.52–99.19)
        ≥5 yearsNA23.03 (1.30–7.04)23.03 (1.30–7.04)
        ≥10 yearsNA31.57 (1.13–2.16)31.57 (1.13–2.16)
        ≥20 yearsNA31.54 (0.97–2.44)31.54 (0.97–2.44)

      NA: not applicable (no study reporting this estimate). #: unadjusted estimates of lung cancer and previous tuberculosis; ¶: adjusted for age and any assessment of smoking; +: adjusted for age and quantitatively assessed smoking; §: hazard ratio for cohort studies and odds ratio for case–control studies; ƒ: pre-specified subgroup analysis.

      Supplementary Materials

      • Figures
      • Tables
      • Supplementary Material

        Please note: supplementary material is not edited by the Editorial Office, and is uploaded as it has been supplied by the author.

        Supplementary material ERR-0025-2022.SUPPLEMENT

      PreviousNext
      Back to top
      View this article with LENS
      Vol 31 Issue 165 Table of Contents
      European Respiratory Review: 31 (165)
      • Table of Contents
      • Index by author
      Email

      Thank you for your interest in spreading the word on European Respiratory Society .

      NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

      Enter multiple addresses on separate lines or separate them with commas.
      Lung cancer occurrence after an episode of tuberculosis: a systematic review and meta-analysis
      (Your Name) has sent you a message from European Respiratory Society
      (Your Name) thought you would like to see the European Respiratory Society web site.
      CAPTCHA
      This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
      Print
      Citation Tools
      Lung cancer occurrence after an episode of tuberculosis: a systematic review and meta-analysis
      Javier Cabrera-Sanchez, Vicente Cuba, Victor Vega, Patrick Van der Stuyft, Larissa Otero
      European Respiratory Review Sep 2022, 31 (165) 220025; DOI: 10.1183/16000617.0025-2022

      Citation Manager Formats

      • BibTeX
      • Bookends
      • EasyBib
      • EndNote (tagged)
      • EndNote 8 (xml)
      • Medlars
      • Mendeley
      • Papers
      • RefWorks Tagged
      • Ref Manager
      • RIS
      • Zotero

      Share
      Lung cancer occurrence after an episode of tuberculosis: a systematic review and meta-analysis
      Javier Cabrera-Sanchez, Vicente Cuba, Victor Vega, Patrick Van der Stuyft, Larissa Otero
      European Respiratory Review Sep 2022, 31 (165) 220025; DOI: 10.1183/16000617.0025-2022
      del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
      Full Text (PDF)

      Jump To

      • Article
        • Abstract
        • Abstract
        • Introduction
        • Methods
        • Results
        • Discussion
        • Supplementary material
        • Footnotes
        • References
      • Figures & Data
      • Info & Metrics
      • PDF

      Subjects

      • Respiratory infections and tuberculosis
      • Lung cancer
      • Tweet Widget
      • Facebook Like
      • Google Plus One

      More in this TOC Section

      • Biologic drugs in treating ABPA in patients with CF
      • Immune processes in the pathogenesis of chronic lung allograft dysfunction
      Show more Reviews

      Related Articles

      Navigate

      • Home
      • Current issue
      • Archive

      About the ERR

      • Journal information
      • Editorial board
      • Reviewers
      • Press
      • Permissions and reprints
      • Advertising
      • Sponsorship

      The European Respiratory Society

      • Society home
      • myERS
      • Privacy policy
      • Accessibility

      ERS publications

      • European Respiratory Journal
      • ERJ Open Research
      • European Respiratory Review
      • Breathe
      • ERS books online
      • ERS Bookshop

      Help

      • Feedback

      For authors

      • Instructions for authors
      • Publication ethics and malpractice
      • Submit a manuscript

      For readers

      • Alerts
      • Subjects
      • RSS

      Subscriptions

      • Accessing the ERS publications

      Contact us

      European Respiratory Society
      442 Glossop Road
      Sheffield S10 2PX
      United Kingdom
      Tel: +44 114 2672860
      Email: journals@ersnet.org

      ISSN

      Print ISSN: 0905-9180
      Online ISSN: 1600-0617

      Copyright © 2022 by the European Respiratory Society