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Smouldering fire or conflagration? An illustrated update on the concept of inflammation in pulmonary arterial hypertension

Frédéric Perros, Marc Humbert, Peter Dorfmüller
European Respiratory Review 2021 30: 210161; DOI: 10.1183/16000617.0161-2021
Frédéric Perros
1Université Paris-Saclay, School of Medicine, Le Kremlin Bicêtre, France
2INSERM UMR S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
3Paris-Porto Pulmonary Hypertension Collaborative Laboratory (3PH), INSERM, Le Kremlin-Bicêtre, France
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Marc Humbert
1Université Paris-Saclay, School of Medicine, Le Kremlin Bicêtre, France
2INSERM UMR S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
4Assistance Publique - Hôpitaux de Paris (AP-HP), Dept of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
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Peter Dorfmüller
5Institut für Pathologie, Universitätklinikum Giessen und Marburg, Giessen, Germany
6Deutsches Zentrum für Lungenforschung (DZL), Giessen, Germany
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  • For correspondence: peter.dorfmuller@patho.med.uni-giessen.de
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Article Information

vol. 30 no. 162
DOI 
https://doi.org/10.1183/16000617.0161-2021
PubMed 
34937704

Published By 
European Respiratory Society
Print ISSN 
0905-9180
Online ISSN 
1600-0617
History 
  • Received July 7, 2021
  • Accepted October 20, 2021
  • Published online December 22, 2021.

Copyright & Usage 
Copyright ©The authors 2021 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Frédéric Perros1,2,3,
  2. Marc Humbert1,2,4 and
  3. Peter Dorfmüller5,6⇑
  1. 1Université Paris-Saclay, School of Medicine, Le Kremlin Bicêtre, France
  2. 2INSERM UMR S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
  3. 3Paris-Porto Pulmonary Hypertension Collaborative Laboratory (3PH), INSERM, Le Kremlin-Bicêtre, France
  4. 4Assistance Publique - Hôpitaux de Paris (AP-HP), Dept of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
  5. 5Institut für Pathologie, Universitätklinikum Giessen und Marburg, Giessen, Germany
  6. 6Deutsches Zentrum für Lungenforschung (DZL), Giessen, Germany
  1. Corresponding author: Peter Dorfmüller (peter.dorfmuller{at}patho.med.uni-giessen.de)
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Vol 30 Issue 162 Table of Contents
European Respiratory Review: 30 (162)
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Smouldering fire or conflagration? An illustrated update on the concept of inflammation in pulmonary arterial hypertension
Frédéric Perros, Marc Humbert, Peter Dorfmüller
European Respiratory Review Dec 2021, 30 (162) 210161; DOI: 10.1183/16000617.0161-2021

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Smouldering fire or conflagration? An illustrated update on the concept of inflammation in pulmonary arterial hypertension
Frédéric Perros, Marc Humbert, Peter Dorfmüller
European Respiratory Review Dec 2021, 30 (162) 210161; DOI: 10.1183/16000617.0161-2021
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • The smouldering fire hypothesis
    • The conflagration hypothesis
    • Targeting inflammation and and dysregulated immunity in PAH
    • Conclusion
    • Acknowledgements
    • Footnotes
    • References
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  • Info & Metrics
  • PDF

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  • Pulmonary vascular disease
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