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vol. 30 no. 161
PubMed
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History
- Received March 19, 2021
- Accepted June 5, 2021
- Published online September 15, 2021.
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Copyright ©The authors 2021 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org
Author Information
- Mareike Gierhardt1,2,3,4,
- Oleg Pak1,2,
- Dieter Walmrath1,
- Werner Seeger1,2,3,5,
- Friedrich Grimminger1,2,
- Hossein A. Ghofrani1,2,6,
- Norbert Weissmann1,2,
- Matthias Hecker1,7 and
- Natascha Sommer1,2,7
- 1Dept of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany
- 2Excellence Cluster Cardio-Pulmonary Institute (CPI), Giessen, Germany
- 3Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) – CONICET – Partner Institute of the Max Planck Society, Buenos Aires, Argentina
- 4Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI) Bad Nauheim, Germany
- 5Institute for Lung Health (ILH), Giessen, Germany
- 6Dept of Medicine, Imperial College London, London, UK
- 7Both authors contributed equally
- Corresponding author: Natascha Sommer (natascha.sommer{at}innere.med.uni-giessen.de)
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Vol 30 Issue 161
Table of Contents
Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome
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- Article
- Abstract
- Abstract
- Clinical definition and current therapeutic options for ARDS
- General pathomechanisms underlying ARDS
- V/Q mismatch in ARDS
- Primary sensing and signalling mechanism underlying HPV and alterations in ARDS
- Endothelial modulators of HPV and pulmonary vascular pressure in ARDS
- Systemic, humoral and pharmacological factors affecting HPV
- Dysregulation of HPV in SARS-CoV-2 infection
- The role of PH in ARDS
- Non-pharmacological approach for treatment of V/Q mismatch
- Pharmacological approach for treatment of V/Q mismatch and PH
- Conclusion: treatment of V/Q mismatch in ARDS – rebalancing vascular function
- Footnotes
- References
- Figures & Data
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