Figures
- FIGURE 1
Flowchart showing the study selection process for the qualitative and quantitative synthesis. LTBI: latent tuberculosis infection.
- FIGURE 2
Mean difference (inverse variance method, random-effects model) between SF-6D utility scores for individuals treated for LTBI compared with patients treated for active TB disease. LTBI: latent tuberculosis infection; SF-6D: Short-Form Six-Dimension; TB: tuberculosis.
- FIGURE 3
Mean difference (inverse variance method, random-effects model) between SF-36 mental health (MH) domain scores for individuals treated for LTBI compared with individuals without TB. LTBI: latent tuberculosis infection; SF-36: 36-item Short-Form Health Survey; TB: tuberculosis.
- FIGURE 4
Mean difference (inverse variance method, random-effects model) between SF-36 physical component summary scores for individuals treated for LTBI compared with patients treated for active TB disease. LTBI: latent tuberculosis infection; PCS: physical component summary; TB: tuberculosis.
Tables
- TABLE 1
Summary of study characteristics and health outcomes instruments
Study design Study location Patients n Recruitment duration Instrument/ measurement Reported health outcome [Ref.] LTBI TB Without TB infection Longitudinal TB clinics, MCI and JGH, Canada 105 48 110 June 2008–October 2011 (40 months) 1) SF-36 → SF-6D utilities
2) SGHRQoL [19]
Health utilities [18][18, 19] Prospective cohort Broward or Palm Beach County Health Dept, Florida, USA 90 August 2005–July 2007 (24 months) 1) Stigma scale from EMIC for Tuberculosis in Haitian Populations Stigma [20] Cross-sectional TB clinic, MCI, Canada 35 22 1 September 1999–30 September 2000 (13 months) 1) VAS
2) SG
3) SF-36
4) EQ-5DHRQoL [21, 22] Qualitative TB-OPD, Karolinska University Hospital, Solna, Sweden 16 December 2017–June 2018 (7 months) Interview guide Treatment experience [23] Longitudinal TB clinic, British Columbia Centre for Disease Control, Canada 102 104 2005–2006 (12 months) 1) SF-36 v2→SF-6D utilities
2) BDI
3) HUI2, HUI3
4) VASHRQoL [24]
Health utilities [25][24, 25] Retrospective TB registries, 20 different sites in the USA 7 282 3853 1993–31 December 2002 (9 years) 1) Mortality risk Mortality [26] Retrospective TB clinic, TCPH, Texas, USA 210 107 7 July 2005–7 November 2006 (16 months) 1) SGRQ HRQoL [27]
QALY [22][27, 28] Cross-sectional Infectious disease or paediatric clinics, Karolinska University Hospital, Sweden 108 19 415 September 2017–June 2018 (10 months) 1) EQ-5D
2) RHS-15HRQoL [29] Cross-sectional Dispensary of TB Kayseri, Turkey 108 196 196 15 September 2003–15 September 2004 (12 months) 1) SF-36
2) BDIHRQoL [30] LTBI: latent tuberculosis infection; TB: tuberculosis; MCI: Montreal Chest Institute; JGH: Jewish General Hospital; SF-36: 36-item Short-Form Health Survey; SF-6D: Short-Form Six-Dimension; SG: standard gamble tasks; HRQoL: health-related quality of life; EMIC: Explanatory Model Interview Catalogue; VAS: visual analogue scale; EQ-5D: EuroQol-5 dimensions; TB-OPD: Tuberculosis outpatient department; SF-36 v2: 36-item Short-Form Health Survey version 2; BDI: Beck Depression Inventory; HUI2: Health Utilities Index Mark 2; HUI3: Health Utilities Index Mark 3; TCPH: Tarrant County Public Health; SGRQ: St George's Respiratory Questionnaire; QALY: quality-adjusted life year; RHS-15: Refugee Health Screener-15.
Supplementary Material
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Supplementary_material ERR-0260-2020_Supplementary_material
