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Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis

Ricardo J. José, Andrew Williams, Ari Manuel, Jeremy S. Brown, Rachel C. Chambers
European Respiratory Review 2020 29: 200240; DOI: 10.1183/16000617.0240-2020
Ricardo J. José
1Centre for Inflammation and Tissue Repair, University College London, London, UK
2Respiratory Medicine, Royal Brompton Hospital, London, UK
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  • ORCID record for Ricardo J. José
  • For correspondence: r.jose@ucl.ac.uk
Andrew Williams
1Centre for Inflammation and Tissue Repair, University College London, London, UK
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Ari Manuel
3University Hospital Aintree, Liverpool, UK
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Jeremy S. Brown
1Centre for Inflammation and Tissue Repair, University College London, London, UK
4Dept of Thoracic Medicine, University College London Hospital, London, UK
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Rachel C. Chambers
1Centre for Inflammation and Tissue Repair, University College London, London, UK
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Article Information

vol. 29 no. 157
DOI 
https://doi.org/10.1183/16000617.0240-2020
PubMed 
33004529

Published By 
European Respiratory Society
Print ISSN 
0905-9180
Online ISSN 
1600-0617
History 
  • Received July 26, 2020
  • Accepted August 20, 2020
  • Published online October 1, 2020.

Copyright & Usage 
Copyright ©ERS 2020. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Ricardo J. José1,2⇑,
  2. Andrew Williams1,
  3. Ari Manuel3,
  4. Jeremy S. Brown1,4 and
  5. Rachel C. Chambers1
  1. 1Centre for Inflammation and Tissue Repair, University College London, London, UK
  2. 2Respiratory Medicine, Royal Brompton Hospital, London, UK
  3. 3University Hospital Aintree, Liverpool, UK
  4. 4Dept of Thoracic Medicine, University College London Hospital, London, UK
  1. Ricardo J. José, Centre for Inflammation and Tissue Repair, UCL Respiratory, University College London, 5 University Street, WC1E 6JF, UK. E-mail: r.jose{at}ucl.ac.uk
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Article usage: October 2020 to March 2021

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Oct 2020611170507
Nov 202013514198
Dec 202056451169
Jan 202141357111
Feb 202142255100
Mar 202157245104

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Vol 29 Issue 157 Table of Contents
European Respiratory Review: 29 (157)
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Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis
Ricardo J. José, Andrew Williams, Ari Manuel, Jeremy S. Brown, Rachel C. Chambers
European Respiratory Review Sep 2020, 29 (157) 200240; DOI: 10.1183/16000617.0240-2020

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Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis
Ricardo J. José, Andrew Williams, Ari Manuel, Jeremy S. Brown, Rachel C. Chambers
European Respiratory Review Sep 2020, 29 (157) 200240; DOI: 10.1183/16000617.0240-2020
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • The TF-dependent pathway
    • TF pathway inhibitors
    • Endogenous anticoagulants and treatment of severe pneumonia and ARDS
    • PARs mediate the interplay between coagulation and inflammation
    • The potential of targeting coagulation in COVID-19
    • Conclusions
    • Footnotes
    • References
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  • Info & Metrics
  • PDF

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