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Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment

Xiang Zheng, Siavash Mansouri, Annika Krager, Friedrich Grimminger, Werner Seeger, Soni S. Pullamsetti, Craig E. Wheelock, Rajkumar Savai
European Respiratory Review 2020 29: 200134; DOI: 10.1183/16000617.0134-2020
Xiang Zheng
1Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany
6These authors contributed equally
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  • ORCID record for Xiang Zheng
Siavash Mansouri
1Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany
6These authors contributed equally
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Annika Krager
1Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany
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Friedrich Grimminger
2Dept of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, Giessen, Germany
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Werner Seeger
1Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany
2Dept of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, Giessen, Germany
3Institute for Lung Health (ILH), Justus Liebig University, Giessen, Germany
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Soni S. Pullamsetti
1Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany
2Dept of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, Giessen, Germany
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Craig E. Wheelock
4Division of Physiological Chemistry 2, Dept of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
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Rajkumar Savai
1Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany
2Dept of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, Giessen, Germany
3Institute for Lung Health (ILH), Justus Liebig University, Giessen, Germany
5Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt, Germany
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  • For correspondence: rajkumar.savai@mpi-bn.mpg.de
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Article Information

vol. 29 no. 157
DOI 
https://doi.org/10.1183/16000617.0134-2020
PubMed 
33004525

Published By 
European Respiratory Society
Print ISSN 
0905-9180
Online ISSN 
1600-0617
History 
  • Received May 5, 2020
  • Accepted August 6, 2020
  • Published online October 1, 2020.

Copyright & Usage 
Copyright ©ERS 2020. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Xiang Zheng1,6,
  2. Siavash Mansouri1,6,
  3. Annika Krager1,
  4. Friedrich Grimminger2,
  5. Werner Seeger1,2,3,
  6. Soni S. Pullamsetti1,2,
  7. Craig E. Wheelock4 and
  8. Rajkumar Savai1,2,3,5⇑
  1. 1Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany
  2. 2Dept of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, Giessen, Germany
  3. 3Institute for Lung Health (ILH), Justus Liebig University, Giessen, Germany
  4. 4Division of Physiological Chemistry 2, Dept of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
  5. 5Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt, Germany
  6. 6These authors contributed equally
  1. Rajkumar Savai, Molecular Mechanisms in Lung Cancer, Dept of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Parkstrasse 1, D-61231 Bad Nauheim, Germany. E-mail: rajkumar.savai{at}mpi-bn.mpg.de
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Vol 29 Issue 157 Table of Contents
European Respiratory Review: 29 (157)
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Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment
Xiang Zheng, Siavash Mansouri, Annika Krager, Friedrich Grimminger, Werner Seeger, Soni S. Pullamsetti, Craig E. Wheelock, Rajkumar Savai
European Respiratory Review Sep 2020, 29 (157) 200134; DOI: 10.1183/16000617.0134-2020

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Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment
Xiang Zheng, Siavash Mansouri, Annika Krager, Friedrich Grimminger, Werner Seeger, Soni S. Pullamsetti, Craig E. Wheelock, Rajkumar Savai
European Respiratory Review Sep 2020, 29 (157) 200134; DOI: 10.1183/16000617.0134-2020
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • TAM metabolism configures the TME and the TME determines the TAM phenotype
    • Metabolic reprogramming of TAMs to favour a tumouricidal phenotype as a potential antitumoural therapeutic strategy
    • Future perspectives
    • Footnotes
    • References
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  • Mechanisms of lung disease
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  • Mitochondrial dysfunction in lung ageing and disease
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